礼来公布替尔泊肽SURMOUNT-2减肥临床试验结果

2023年4月27日礼来（Eli Lilly）公司公布了替尔泊肽（Tirzepatide）SURMOUNT-2临床试验的结果。经过72周的治疗，10mg替尔泊肽剂量组的平均减重幅度达到13.4%，15mg替尔泊肽剂量的平均减重幅度达到…

发布时间：2023-04-27浏览数：1k+

替尔泊肽成为首个减重记录接近减重手术的药物

2021年美格鲁肽（Semaglutide）STEP 4临床试验，将药物减重的记录刷新到17.4%。2022年替尔泊肽（Tirzepatide）SURMOUNT-1试验，再次将药物减重的记录刷新到20.9%，成为首个减重记录接近减重手术的…

发布时间：2022-07-21浏览数：1k+

Donanemab in Early Alzheimer's Disease

In patients with early Alzheimer's disease, donanemab resulted in a better composite score for cognition and for the ability to perform activities of daily living than placebo at 76…

发布时间：2021-05-06浏览数：649

司美格鲁肽第一个减重超过15%的减肥药物

在STEP 4试验结果发表之前，减肥药物多为小分药物，小分药物的最高试验减重记录长期徘徊在10%左右。STEP 4试验显示，司美格鲁肽治疗组患者平均体重与治疗前相比降低了17.4%，成为第一个减重超过1…

发布时间：2021-04-13浏览数：1k+

Donanemab (LY3002813) dose-escalation study in Alzheimer's disease

Intravenous donanemab 10 mg/kg can reduce amyloid deposits in AD despite having a shorter than expected half-life.

发布时间：2021-02-14浏览数：815

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association

Stage 1 is defined as the presence of β-cell autoimmunity as evidenced by the presence of two or more islet autoantibodies with normoglycemia and is presymptomatic, stage 2 as the …

发布时间：2015-12-01浏览数：519

1型糖尿病分期标准

1型糖尿病（T1DM）分期标准不仅为临床实践也为T1DM预防药物，如抗CD3抗体药物的开发提供了重要的理论依据。

发布时间：2015-12-01浏览数：671

A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice

These studies have profound implications for the development of therapeutic Aβ antibodies for Alzheimer's disease.

发布时间：2012-01-06浏览数：779

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques

A beta N3(pE) production and retention may play an early and critical role in senile plaque formation.

发布时间：1995-02-01浏览数：674